Like its two predecessors, it is an action and adventure game of the type Survival Horror, where the protagonist on this occasion is Jill Valentine, who has to escape from a city plagued by zombies infected by the T virus. In this video game, Jill you will have to deal not only with the hordes of zombies and infected creatures by the virus, but you will also have to face a new enemy: NEMESIS, a biological weapon that is programmed to destroy the members of STARS that so many problems have caused Umbrella.